Impact of toxicity effects of zinc oxide nanoparticles in rats within acute and subacute experiments

Introduction. Occupational air is contaminated with zinc oxide nanoparticles in the copper smelting industry, especially of brass and copper. A wide range toxic effects varied clinical symptomatology observed its compounds. Competitive relations many other metals, including calcium, copper, iron, are foundation most cases intoxication. Long-term administration or compounds to laboratory rodents affects enzymes, carbohydrates mineral metabolism. Materials methods. Subchronic intoxication repeated intraperitoneal injections acute low respiratory tract reaction a single intratracheal injection were simulated outbred white rats. Water suspensions 30-80 nm diameter applied both experimental models. Upon completion exposure, condition rats all groups was evaluated generally accepted criteria for toxicity. The student’s t-test statistical analysis obtained data. Results. Moderate development subchronic experiment demonstrated. Homogeneous ultrastructural changes spleen tissue revealed. Mitochondrial damage partial complete loss crista common. fragmentation ratio DNA found by statistically significant increase. revealed increase attraction cells capable their phagocytosis (mainly neutrophils) into tract. This shows cytotoxicity. Conclusion. general cytotoxic on rat body identified.